They already knew prescription-only doses of naproxen were associated with gastrointestinal toxicity, but researchers at Stanford University wanted to know more about the potential dangers of lower dosages.
What they found was that doses under the prescription strength of 1,000 mg per day significantly increased the risk of gastric or duodenal ulcers.
According to one researcher quoted in a story from Medpage Today, “naproxen use is not safe even at lower doses.”
In fact, researchers found naproxen caused hospitalization with complications such as hemorrhage, perforation or obstruction.
All doses of naproxen increased the risk for ulcers:
- More than a 3-fold at 1,000 mg per day
- Nearly 3-fold at 750 mg per day
- 2.5-fold at 500 mg per day